トップページ 業績(英文)

原著・総説 (2006-2008)
240.Hozumi Y, Fukaya M,Adachi N, Saito N, Otani K, Kondo H, Watanabe M, Goto K: Diacylglycerol kinase beta accumulates on the perisynaptic site of medium spiny neurons in the striatum. Eur J Neurosci. 28:2409-2422,2008. [PMID:19087171]
239.Polgar E, Al-KhaterK, Shehab S, Watanabe M, Todd AJ: Large projection neurons in laminaI of the rat spinal cord that lack the neurokinin 1 receptor are denselyinnervated by VGLUT2-containing axons and possess GluR4-containing AMPAreceptors. J. Neurosci. 28:13150-13160,2008. [PMID:19052206]
238.Shinohara Y, HiraseH, Watanabe M, Itakura M, Takahashi M, Shigemoto R: Left-rightasymmetry of the hippocampal synapses with different subunit allocation ofglutamate receptors. Proc. Natl. Acad.Sci. USA. 105:19498-19503.2008. [PMID:19052236]
237.Shi TJ, Liu SX, HammarbergH, Watanabe M, Xu ZQ, Hokfelt T: Phospholipase CB3 in mouse and human dorsal rootganglia and spinal cord is a possible target for treatment of neuropathic pain. Proc.Natl. Acad. Sci. USA.105:20004-20008, 2008. [PMID:19066214 ]
236.Fukaya M, Uchigashima M, Nomura S, Hasegawa Y,Kikuchi H, Watanabe M: Predominantexpression of phospholipase Cb1 in telencephalic principal neurons andcerebellar interneurons, and its close allocation with related signalingmolecules in somatodendritic neuronal elements. Eur. J. Neurosci. 28:1744-1759,2008. [PMID:18973591 ]
235.Tamai K, Tanaka N,Toyoshima M, Yamamoto N, Owada Y, Kiyonari H, Ueno Y, Ono M,Shimosegawa T, Watanabe M, Sugamura K: Loss of Hrs in the central nervoussystem causes accumulation of ubiquitinated proteins and neurodegeneration. Am. J. Pathol. 173:1806-1817, 2008.[PMID:19008375]
234.Tachikawa M, Fujinawa J, Takahashi M, KasaiY, Fukaya M, Sakai K, Yamazaki M, Tomi M, Watanabe M, Sakimura K,Terasaki T, Hosoya K: Expression and possible role of creatine transporter inthe brain and at the blood-cerebrospinal fluid barrier as a transportingprotein of guanidinoacetate, an endogenous convulsant. J. Neurochem. 107:768-778, 2008. [PMID:18761709]
233.Nogueiras R, Veyrat-Durebex C, Suchanek PM, Klein M, Tschop J, Caldwell C, WoodsSC, Wittmann G, Watanabe M, Liposits Z, Fekete C, Reizes O, Rohner-Jeanrenaud F,Tschop MH: Peripheral, but not central, CB1 antagonism provides foodintake-independent metabolic benefits in diet-induced obese rats. Diabetes. 57:2977-2991, 2008. [PMID:18716045]
232.Shimizu H, Fukaya M, Yamasaki M, WatanabeM, Manabe T, Kamiya H: Use-dependent amplification of presynaptic Ca2+signaling by axonal ryanodine receptors at the hippocampal mossy fiber synapse. Proc. Natl. Acad. Sci. USA. 105:11998-12003,2008. [PMID:18687898]
231.Watase K, Barrett CF, Miyazaki T,Ishiguro T, Ishikawa K, Hu Y, Unno T, Sun Y, Kasai S, Watanabe M, Gomez CM,Mizusawa H, Tsien RW, Zoghbi HY: Spinocerebellarataxia type 6 knock-in mice develop a progressive neuronal dysfunction withage-dependent accumulation of mutant CaV2.1 channels. Proc. Natl. Acad. Sci. USA.105:11987-11992, 2008. [PMID:18687887]
230.Takeuchi,T., Ohtsuki, G., Yoshida, T., Fukaya, M., Wainai, T.,Yamashita M, Yamazaki Y, Mori, M., Sakimura, K., Kawamoto, S., Watanabe, M.,Hirano, T., Mishina, M. Enhanced cerebellar LTD induction and OKR adaptation inmice lacking delphilin. PLoS One. 3:e2297,2008. [PMID:18509461]
229.Katano T,Furue H, Okuda-Ashitaka E, Tagaya M, Watanabe M, Yoshimura M, Ito S:N-Ethylmaleimide-sensitive fusion protein (NSF) is involved in centralsensitization in the spinal cord through GluR2 subunit composition switch afterinflammation. Eur. J. Neurosci. 27:3161-3170,2008. [PMID:18598260]
228.Ito-Ishida A, Miura E, Emi K,Matsuda K, Iijima K, Narumi S, Kondo T, Kohda K, Watanabe M, Yuzaki M: Cbln1Regulates Rapid Formation and Maintenance of Excitatory Synapses in MatureCerebellar Purkinje Cells in vitro and in vivo. J. Neurosci. 28:5920-5930, 2008. [PMID:18524896]
227.Mao P, Tao Y-X, Fukaya M, Li D,Tao T, Watanabe M, Johns RA: Cloning and characterization ofE-dlg, a novel splice variant of mouse homologue of the Drosophila discs largetumor suppressor binds preferentially to SAP102. IUBMB. (International Union of Biochemistry andMolecular Biology) Life. 60:684-692, 2008. [PMID:18618587]
226.PatriziA, Scelfo B, Viltono L, Briatore F, Fukaya M, Watanabe M, Strata P, Varoqueaux F, Brose N,Fritschy JM, Sassoe-Pognetto M: Synapse formation and clusteringof neuroligin-2 in the absence of GABAAreceptors. Proc.Natl. Acad. Sci. USA. 105:13151-13156, 2008. [PMID:18723687]
225.Cueni L, Canepari M,Lujan R, Watanabe M, Bond CT, Adelman JP, Luthi A: Dual coupling ofT-type Ca2+ channels shapes sleep-related oscillations in thalamicdendrites. Nature Neurosci.11:683-692,2008. [PMID:18488023]
224.Takasaki C, Okada R, Mitani A, Fukaya M,Yamasaki M, Fujihara Y, ShirakawaT, Tanaka K, Watanabe M. Glutamatetransporters regulate lesion-induced period plasticity in the developing somatosensorycortex. J. Neurosci. 28:4995-5006,2008. [PMID:18463253 ]
223.Aguado C, Colon J, Ciruela F,Schlaudraff F, Cabanero MJ, Perry C, Watanabe M, Liss B, Wickman K, Lujan R:Cell type-specific subunit composition of G-protein-gated potassium channels inthe cerebellum. J Neurochem.105:497-511,2008. [PMID:18088366]
222.Miwa H, Fukaya M, Watabe AM, WatanabeM, Manabe T: Functional contributions of synaptically localized NR2B subunitsof the NMDA receptor to synaptic transmission and long-term potentiation in theadult mouse CNS. J. Physiol.586:2539-2550, 2008. [PMID:18372311]
221.Matsuda S, Miura E, Matsuda K,Kakegawa W, Kohda K, Watanabe M, Yuzaki M: Accumulation of AMPA receptors inautophagosomes in neuronal axons lacking adaptor protein AP4. Neuron. 57:730-745, 2008. [PMID:18341993]
220.Yasumura M, Uemura T, Yamasaki M,Sakimura K, Watanabe M, Mishina M: Role of the internal Shank-binding segmentof glutamate receptor d2 in synaptic localization andcerebellar functions. Neurosci. Lett. 433:146-151, 2008.[PMID:18249497]
219.Tomioka Y, MiyazakiM, Taharaguchi S, Yoshino S, Morimatsu M, Uede T, Ono E, Watanabe M: Cerebellarpathology in transgenic mice expressing the pseudorabies virus immediate-earlyprotein IE180. Eur. J. Neurosci. 27:2115-2132,2008. [PMID:18412631 ]
218.Polgar E, Watanabe M, Hartmann B,Grant SGN, Todd TA: Expression of AMPA receptor subunits at synapses in laminaeI-III of the rodent spinal dorsal horn. Mol.Pain.4:5, 2008. [PMID:18215271] (on-line journal)
217.WatanabeF, Miyazaki T, Takeuchi T, Fukaya M, Nomura T, Noguchi S, Mori H, Sakimura K, WatanabeM, Mishina M: Effects of FAK ablation on cerebellar foliation, Bergmann gliapositioning and climbing fiber territory on Purkinje cells. Eur. J. Neurosci. 27:836-854, 2008.[PMID:18279360]
216.Lin MT, Lujan R, Watanabe M, Adelman JP,Maylie J: SK2 channel plasticitycontributes to LTP at Shaffer collateral-CA1 synapses. Nature Neurosci. 11:170-177, 2008. [PMID:18204442]
215.Nyilas R, Dudok B, Urban GM, MackieK, Watanabe M, Cravatt BF , Freund TF, Katona I: Enzymatic machineryfor endocannabinoid biosynthesis associated with calcium stores inglutamatergic axon terminals. J. Neurosci. 28:1058-1063, 2008. [PMID:18234884]
214.Ludanyi A, Erass L,Czirjak S, Vajda J, Halasz P, Watanabe M, Palkovits M, Magloczky Z,Freund TF, Katona I: Downregulationof the CB1 cannabinoid receptor and related molecular elements of theendocannabinoid system in epileptic human hippocampus. J. Neurosci. 28:2976-2990, 2008. [PMID:18354002]
213.Sakagami H, Sanda M, Fukaya M, Miyazaki T, Sukegawa J, Yanagisawa T, Suzuki T,Fukunaga K, Watanabe M, Kondo K: IQ-ArfGEF/BRAG1 is a guanine nucleotideexchange factor for Arf6 that interacts and localizes with PSD-95 at excitatorysynapses. Neurosci. Res. 60:199-212,2008. [PMID:18164504]
212.Kakegawa W, Miyazaki T, Emi K, Matsuda K, Kohda K, Motohashi J, Mishina M,Kawahara S, Watanabe M, Yuzaki M. Differential regulation of synapticplasticity and cerebellar motor learning by the C-terminal PDZ-binding motif ofGluRd2.J Neurosci. 28:1460-1468,2008. [PMID:18256267 ]
211.Matyas F, Urban GM, Watanabe M, Mackie K, Aimmer A, Freund TF, Katona I:Multiple substrates for synaptic cannabinoid signaling in dopaminergic andnon-dopaminergic neurons of the ventral tegmental area. Neuropharmacology.54:95-107, 2008. [PMID:17655884]
原著・総説 (2007)
210.Kamikubo Y, Tabata T, Kakizawa S, Kawakami D, Watanabe M, Ogura A,Iino M, Kano M: Postsynaptic GABAB receptor signalling enhances LTD in mousecerebellar Purkinje cells. J Physiol. 585:549-563,2007. [PMID:17947316]
209.LabouebeG, Lomazzi M, Cruz HG, Lujan R, Li M, Yanagawa Y., Obata K., WatanabeM, Wickman K, Slesinger P, Luscher C: RGS2 modulates GABAB receptor-GIRKchannel coupling in dopamine neurons of the ventral tegmental area. Nature Neurosci. 10:1559-1568, 2007.[PMID:17965710]
208.Konno,K., Matsumoto, M., Togashi, H., Yamaguchi, T., Izumi, T., Watanabe,M., Iwanaga, T., Yoshioka, M. Early postnatal stress affects the serotonergicfunction in the median raphe nuclei of adult rats. Brain Res. 1172:60-66, 2007. [PMID:17825274]
207.Uemura T, Kakizawa T, Yamasaki M, Sakimura K, Watanabe M, Iino M, Mishina M.Regulation of long-term depression and climbing fiber territory by GluRd2at parallel fiber synapses through its cariboxyl terminal domain in cerebellarPurkinje cells. J Neurosci. 27:12096-12108,2007. [PMID:17978051]
206.Ikeda A, Miyazaki T, Kakizawa S, Okuno Y, Tsuchiya S, Myomoto A,Saito S, Yamamoto T, Yamazaki T, Iino M, Tsujimoto G, Watanabe M, Takeshima H:Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins. Biochem. Biophys. Res. Commun.363:835-839,2007. [PMID:17904530]
205.Nishiyama H, Fukaya M, Watanabe M, Linden D: Axonal motility and its modulation by activityare branch-type specific in the intact adult cerebellum. Neuron. 56:472-487, 2007. PMID: 1798863]
204.NishiyamaJ, Miura E, Mizushima N, Watanabe M, Yuzak M: Aberrant membranes and double-membranestructures accumulate in the axons of Atg5-null Purkinje cells before neuronaldeath. Autophagy. 3:591-596, 2007. [PMID:17912025]
203.MakaraJK, Katona I, Nyiri G, Nemeth B, Watanabe M, Vente J de, Freund TF,Hajos N: Involvement of nitric oxide in depolarization-induced suppression ofinhibition in hippocampal pyramidal cells. J. Neurosci. 27:10211-10222, 2007. [PMID:17881527]
202.Fukui Y, Takao K, Fukaya M,Hynynen MN, Churchill MJ, Shefner JM, Bronson RT, Watanabe M, Brown Jr R,Miyakawa T, Itohara S, Hayashi Y: Genetic ablation of NMDA receptor subunitNR3B in mouse reveals motoneuronal and non-motoneuronal phenotypes. Eur. J. Neurosci. 26:1407-1420. 2007.[PMID:17880385]
201.Uchigashima M, Fukaya M,Watanabe M, Kamiya H: Evidence against GABA release from glutamatergic mossyfiber terminals in the developing hippocampus. J. Neurosci. 27:8088-8100, 2007. [PMID:17652600 ]
200.Nakamura, K., Hirai, H., TorashimaT., Miyazaki, T., Tsurui, H., Xiu, Y., Ohtsuji, M., Lin, Q.S., Tsukamoto, K.,Nishimura, H., Ono, M., Watanabe, M., Hirose, S. CD3 and IgG Fc receptorregulate cerebellar functions. Mol. CellBiol. 27:5128-5134, 2007. [PMID:17502348]
199.Brumovsky P, Watanabe M, Hokfelt T: Expression of the vesicular glutamatetrasporters-1 and -2 in adult mouse dorsal root ganglia and spinal cord andtheir regulation by nerve injury. Neuroscienc.e147:469-490, 2007. [PMID:17577523]
198.Wittmann, G., Deli, L., Kallo, I., Hraboviszky, E., Watanabe, M., Loposits, Z.,Fekete, C. Distribution of type 1 cannabinoid receptor (CB1) immunoreactiveaxons in the mouse hypothalamus. J. Comp. Neurol. 503:270-279, 2007. [PMID:17492633]
197.UchigashimaM, Narushima M, Fukaya M, Katona I, Kano M, Watanabe M: Subcellular arrangementof molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and itsphysiological contribution to synaptic modulation in the striatum. J. Neurosci. 27:3663-3676, 2007.[PMID:17409230 ]
196.PolgarE, Campbell AD, MacIntyre LM, Watanabe M, Todd AJ: Phosphorylationof extracellular signal-regulated kinase in neurokinin 1 receptor-expressingneurons in laminae III and IV of the rat spinal dorsal horn following noxiousstimulation. Mol. Pain. 3:4, 2007.[PMID:17309799]
195.Marzban, H., Chung, S., Watanabe, M., Hawkes, R. Phospholipase Cb4expression reveals the continuity of cerebellar topography through development. J. Comp. Neurol.502:857-871, 2007.[PMID:17436294]
194.Kakizawa,S. Kishimoto, Y., Hashimoto, K., Miyazaki, T. Furutani, K., ShimizuH, Fukaya M, Nishi, M., Sakagami, H., Ikeda A, Kondo, H., Kano, M., Watanabe, M.,Iino, M., Takeshima, H. Junctophilin-mediated channel crosstalk essential forcerebellar synaptic plasticity. EMBO J.26:1924-1933, 2007. [PMID:17347645]
193.TakasakiC, Miura E, Watanabe M: Segmental and complementary expression ofL-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase and neutral aminoacid transporter ASCT1 in the mouse kidney. Biomed. Res. 28:61-69, 2007. [PMID:17510490]
192.KakegawaW, Miyazaki T., Hirai H, Motohashi J, Mishina M, Watanabe M, YuzakiM: Ca2+ permeability of the channel pore is not essential for the d2glutamate receptor to regulate synaptic plasticity and motor coordination. J. Physiol. (London). 579:729-735, 2007.[PMID:17255161]
191.Iijima T, Miura E, MatsudaK, Kondo T, Kamekawa Y, Watanabe M, Yuzaki M: Characterization of atransneuronal cytokine family Cbln. regulation of secretion by heteromericassembly. Eur. J. Neurosci. 25:1049-1057,2007. [PMID:17331201 ]
190.TakagishiY, Hashimoto H, Kayahara T, Watanabe M, Otsuka H, Mizoguchi A, KanoM, Murata Y: Diminished climbing fiber innervation of Purkinje cells in thecerebellum of myosin Va mutant mice and rats. Dev. Neurobiol. 67:909-923m 2007. [PMID:17506494]
189.NomuraS, Fukaya M, Tsujioka T, Wu D, Watanabe M: Phospholipase CB3 is distributed inboth somatodendritic and axonal compartments and localized around perisynapseand smooth endoplasmic reticulum in mouse Purkinje cell subsets. Eur. J. Neurosci.25:659-672, 2007.[PMID:17298601 ]
188.Masugi-Tokita M, Tarusawa E, Watanabe M, Molnar E, Fujimoto K, Shigemoto R:Number and density of AMPA receptors in individual synapses in the cerebellumas revealed by SDS-digested freeze-fracture replica labeling. J. Neurosci. 27:2135-2144, 2007. [PMID:17314308]
187.NarushimaM, Uchigashima M, Matsui M, Manabe T, Watanabe M, Kano M:Tonic enhancement of endocannabinoid-mediated retrograde suppression ofinhibition by cholinergic interneuron activity in the striatum. J. Neurosci. 27:496-506, 2007. [PMID:17234582 ]
186.TakagakiK, Shima H, Tanuma N, Nomura M, Satoh T, Watanabe M, Kikuchi K:Characterization of a novel low-molecular-mass dual specificity phosphatase-4(LDP-4) expressed in brain. Mol. Cell.Biochem. 296:177-184, 2007. [PMID:17001450]
原著・総説 (2006)
185.Asashima T, Hori S, Ohtsuki S,Tachikawa M, Watanabe M, Mukai C, Kitagaki S, Miyakoshi N, Terasaki T:ATP-binding cassette transporter G2 mediates the efflux of phototoxins on theluminal membrane of retinal capillary endothelial cells. Pharmacol. Res. 23:1235-1242,2006. [PMID:16715370]
184.Matsugami TR,Tanemura K, Mieda M, Nakatomi R, Yamada K, Kondo K, Ogawa M, ObataK, Watanabe M, Hashikawa T, Tanaka K: Indispensability of glutamate transporterGLAST and GLT1 to brain development. Proc.Natl. Acad. Sci. USA. 103:12161-12166, 2006. [PMID:16880397]
183.NarushimaM, Uchigashima M, Hashimoto K, Watanabe M, Kano M: Depolarization-inducedsuppression of inhibition mediated by endocannabinoid at synapses fromfast-spiking interneurons to medium spiny neurons in the striatum. Eur. J. Neurosci. 24:2246-2252,2006. [PMID:17042791]
182.Fukaya M, Tsujita M, Yamazaki M, Kushiya E, AbeM, Akashi K, Natsume R, Kano M, Kamiya H, Watanabe M, Sakimura K: Abundant distribution of TARPg-8in synaptic and extrasynaptic surface of hippocampal neurons and its major rolein AMPA receptor expression on spines and dendrites. Eur. J. Neurosci. 24:2177-2190, 2006. [PMID:17074043 ]
181.Miyazaki T, Hashimoto K, Uda A,Sakagami H, Nakamura Y, Saito S, Nishi M, Kume H, Tohgo A, Kaneko I, Kondo H,Fukunaga K, Kano M, Watanabe M, Takeshima H: Disturbance of cerebellar synapticmaturation in mutant mice lacking BSRPs, a novel brain-specific receptor-likeprotein family. FEBS Lett. 580:4057-4064,2006. [PMID:16814779]
180.Moriguchi S, Nishi M, Komazaki S, Sakagami H, Miyazaki T, Masumiya H, SaitoS, Watanabe M, Kondo H, Yawo H, Fukunaga K, Takeshima H:Functional uncoupling between Ca2+ release andafterhyperpolarization in mutanthippocampal neurons lacking junctophilins. Proc.Natl. Acad. Sci. USA. 103:10811-10816, 2006. [PMID:16809425]
179.Miura E, Iijima T,Yuzaki M, Watanabe M: Distinct expression of Cbln family mRNAs in developingand adult mouse brains. Eur. J. Neurosci. 24:750-760, 2006. [PMID:16930405]
178.Nakazawa T, Komai S, Watabe AM,Kiyama Y, Fukaya M, Arima-Yoshida F, Horai R, Sudo K, Ebine K, Delawary M, GotoJ, Umemori H, Tezuka T, Iwakura Y, Watanabe M, Yamamoto T, Manabe T: NR2Btyrosine phosphorylation modulates fear learning as well as amygdaloid synapticplasticity. EMBO J. 25:2867-2877,2006. [PMID:16710293]
177.Sasaki H, Hozumi Y, Hasegawa H, ItoT, Takagi M, Ogino T, Watanabe M, Goto K: Gene expression and localization ofdiacylglycerol kinase isozymes in the rat spinal cord and dorsal root ganglia. Cell Tissue Res. 326:35-42, 2006.[PMID:16758180]
176.Yoshimura K, Shibata M, Koike M,Gotoh K, Fukaya M, Watanabe M, Uchiyama Y: Effects of RNA interference of Atg4Bon the limited proteolysis of LC3 in PC12 cells an expression of Atg4B invarious rat tissues. Autophagy. 2:200-208,2006. [PMID:16874114]
175.Brumovsky PR, Hygge-Brakeman K,Villar MJ, Watanabe M, Wiesenfeld-Hallin Z, Hokfelt T: Phenotyping of sensoryand sympathetic ganglion neurons of a galanin-overexpressing mouse-Possibleimplications for pain processing. J. Chem. Neuroanat. 31:243-262, 2006. [PMID:16546349]
174.Yoshida T, Fukaya M, Uchigashima M, Kamiya H,Kano M, Watanabe M: Localization of diacylglycerol lipase-a around postsynaptic spinesuggests close proximity between production site of an endocannabinoid,2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. J. Neurosci. 26:4740-4751,2006. [PMID:16672646 ]
173.Nakano T, Hozumi Y, Ali H,Saino-Saito S, Kamii H, Sato S, Kayama T, Watanabe M, Kondo H, Goto K:Diacylglycerol kinase Z is involved in the process of cerebral infarction. Eur. J. Neurosci. 23:1427-1435, 2006.[PMID:16553606]
172.Miura E, Fukaya M, Sato T, SugiharaK, Asano M, Yoshioka K, Watanabe M: Expression and distribution ofJNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain. J. Neurochem. 97:1431-1446, 2006.[PMID:16606357]
171.Kawamura Y, Fukaya M, Maejima T,Yoshida T, Miura E, Watanabe M, Ohno-Shosaku T, Kano M: CB1 is the majorcannabinoid receptor at excitatory presynaptic site in the hippocampus andcerebellum. J. Neurosci. 26:2991-3001,2006. [PMID:16540577]
170.Akagi T, Ishida K, Hanasaka T,Hayashi S, Watanabe M, Hashikawa T, Tohoyama K: Improved methods forultracryotomy of CNS tissue for ultrastructural and immunogold analyses. .J Neurosci. Methods. 153:276-282, 2006.[PMID:16406042]
169.Tohgo A, Eiraku M, Miyazaki T, MiuraE, Ono K, Kawaguchi S, Nishi M, Watanabe M, Hirano T, Kengaku M, Takeshima H:Impaired cerebellar functions in mutant mice lacking DNER. Mol. Cell. Neurosci. 31:326-333, 2006. [PMID:16298139]
168.Sarna JT, Marzban H, Watanabe M,Hawkes R: Complementary stripes of phospholipase Cb3 and Cb4expression by Purkinje cell subsets in the mouse cerebellum. J. Comp. Neurol. 496:303-313, 2006.[PMID:16566000]